Issue 78, 2012
From the journal:

Chemical Communications

A nanoscale graphene oxide–peptide biosensor for real-time specific biomarker detection on the cell surface†

Zhe Wang,abc   Peng Huang,ab   Ashwinkumar Bhirde,b   Albert Jin,d   Ying Ma,b   Gang Niu,b   Nouri Neamati*c  and  Xiaoyuan Chen*b  

* Corresponding authors

a Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China

b Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA
E-mail: shawn.chen@nih.gov
Fax: +1 301-480-1613
Tel: +1 301-451-4246

c Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, Los Angeles, CA, USA
E-mail: neamati@usc.edu
Fax: +1 323-442-1390
Tel: +1 323-442-2341

d Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (NIH), Bethesda, MD, USA

Abstract

A nanoscale RGD–pyrene–graphene oxide (GO) biosensor was prepared for real-time in situ detection of a cancer cell surface marker, integrin αvβ3. This nanoscale GO-based biosensor is simple, robust, sensitive and of high selectivity. It can also be adapted to other cancer cell surface marker evaluation systems.

Graphical abstract: A nanoscale graphene oxide–peptide biosensor for real-time specific biomarker detection on the cell surface

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Article information

DOI
https://doi.org/10.1039/C2CC31974H
Article type
Communication
Submitted
18 Mar 2012
Accepted
07 Aug 2012
First published
08 Aug 2012

Chem. Commun., 2012,48, 9768-9770

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A nanoscale graphene oxide–peptide biosensor for real-time specific biomarker detection on the cell surface

Z. Wang, P. Huang, A. Bhirde, A. Jin, Y. Ma, G. Niu, N. Neamati and X. Chen, Chem. Commun., 2012, 48, 9768 DOI: 10.1039/C2CC31974H

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