Issue 51, 2012

Facile preparation of non-self-quenching fluorescent DNA strands with the degree of labeling up to the theoretic limit

Abstract

A new aggregation-induced emission (AIE) compound 1,1-dimethyl-2,5-bis[4-(isothiocyanatemethyl)phenyl]-3,4-diphenylsilole (SITC) was synthesized and used to conjugate with aminoallyl-dUTP. The SITC–dUTP can be incorporated enzymatically into DNA strands with the degree of labeling (DOL) up to the theoretic limit.

Graphical abstract: Facile preparation of non-self-quenching fluorescent DNA strands with the degree of labeling up to the theoretic limit

Supplementary files

Article information

Article type
Communication
Submitted
20 Mar 2012
Accepted
04 May 2012
First published
04 May 2012

Chem. Commun., 2012,48, 6360-6362

Facile preparation of non-self-quenching fluorescent DNA strands with the degree of labeling up to the theoretic limit

Y. Yu, J. Liu, Z. Zhao, K. M. Ng, K. Q. Luo and B. Z. Tang, Chem. Commun., 2012, 48, 6360 DOI: 10.1039/C2CC32038J

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