Issue 53, 2012
From the journal:

Chemical Communications

Interaction between GUVs and catanionic nanocontainers: new insight into spontaneous membrane fusion†

Chloé Mauroy,‡ab   Pauline Castagnos,‡a   Marie-Claire Blache,b   Justin Teissié,b   Isabelle Rico-Lattes,a   Marie-Pierre Rols*b  and  Muriel Blanzat*a  

* Corresponding authors

a Laboratoire IMRCP, UMR 5623 CNRS, Université Toulouse 3, 118 route de Narbonne, 31062 Toulouse, France
E-mail: blanzat@chimie.ups-tlse.fr
Fax: +33 5 61 55 81 55
Tel: +33 5 61 55 73 75

b Cellular Biophysics, IPBS, UMR 5089 CNRS, Université Toulouse 3, 205 route de Narbonne, BP 64182, 31077 Toulouse, France
E-mail: Marie-Pierre.Rols@ipbs.fr
Fax: +33 5 61 17 59 94
Tel: +33 5 61 17 58 11

Abstract

Spontaneous receptor-free membrane fusion with pure lipid systems, used as a cell membrane model, is demonstrated with easy-to-handle lactose-derived catanionic vesicles. This fusion, mediated and controlled by phospholipids, emphasizes the great value of these nanovesicles for enhanced direct cytosolic drug delivery without the shortcomings linked with endocytic pathways.

Graphical abstract: Interaction between GUVs and catanionic nanocontainers: new insight into spontaneous membrane fusion

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Article information

DOI
https://doi.org/10.1039/C2CC32093B
Article type
Communication
Submitted
22 Mar 2012
Accepted
14 May 2012
First published
15 May 2012

Chem. Commun., 2012,48, 6648-6650

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Interaction between GUVs and catanionic nanocontainers: new insight into spontaneous membrane fusion

C. Mauroy, P. Castagnos, M. Blache, J. Teissié, I. Rico-Lattes, M. Rols and M. Blanzat, Chem. Commun., 2012, 48, 6648 DOI: 10.1039/C2CC32093B

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