Issue 50, 2012
From the journal:

Chemical Communications

A robust, high-sensitivity stealth probe for peptidases†

Oliver Thorn-Seshold,a   Monica Vargas-Sanchez,a   Sean McKeona  and  Jens Hasserodt*a  

* Corresponding authors

a Laboratoire de Chimie, CNRS, École Normale Supérieure de Lyon, 46 Allée d’Italie, F-69364 Lyon, France
E-mail: jens.hasserodt@ens-lyon.fr
Fax: +33 4 7272 8860
Tel: +33 4 7272 8394

Abstract

A robust, modular fluorogenic probe system has been developed which allows the highly sensitive off–ON detection of aminopeptidase activity by releasing an exceptionally photostable, insoluble, phenolic ESIPT fluorophore. The probes generate no false positive signal in over 24 hours, but when activated give a signal within 10 minutes.

Graphical abstract: A robust, high-sensitivity stealth probe for peptidases

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Article information

DOI
https://doi.org/10.1039/C2CC32227G
Article type
Communication
Submitted
27 Mar 2012
Accepted
01 May 2012
First published
02 May 2012

Chem. Commun., 2012,48, 6253-6255

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A robust, high-sensitivity stealth probe for peptidases

O. Thorn-Seshold, M. Vargas-Sanchez, S. McKeon and J. Hasserodt, Chem. Commun., 2012, 48, 6253 DOI: 10.1039/C2CC32227G

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