Issue 65, 2012
From the journal:

Chemical Communications

Coupling of enamides with alkynes or arynes for synthesis of substituted pyridines and isoquinolinesviaamide activation†

Mi-Na Zhao,a   Zhi-Hui Ren,a   Yao-Yu Wanga  and  Zheng-Hui Guan*a  

* Corresponding authors

a Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069, P. R. China
E-mail: guanzhh@nwu.edu.cn

Abstract

A novel and general procedure for Cu-catalyzed coupling of enamides with alkynes to synthesize substituted pyridines was developed. The chemistry was allowed to extend to the synthesis of substituted isoquinolines by coupling of enamides with arynes under transition-metal-free conditions.

Graphical abstract: Coupling of enamides with alkynes or arynes for synthesis of substituted pyridines and isoquinolines via amide activation

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Article information

DOI
https://doi.org/10.1039/C2CC33768A
Article type
Communication
Submitted
25 May 2012
Accepted
26 Jun 2012
First published
27 Jun 2012

Chem. Commun., 2012,48, 8105-8107

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Coupling of enamides with alkynes or arynes for synthesis of substituted pyridines and isoquinolines via amide activation

M. Zhao, Z. Ren, Y. Wang and Z. Guan, Chem. Commun., 2012, 48, 8105 DOI: 10.1039/C2CC33768A

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