Issue 68, 2012

Total synthesis of (±)-pallambins C and D

Abstract

The first total synthesis of (±)-pallambins C and D has been accomplished in a linear 38 step reaction from (±)-Wieland–Miescher ketone. The key conversions are featured as follows: a Grob fragmentation–intramolecular aldol cyclization and a thiourea/palladium-catalyzed carbonylative annulation.

Graphical abstract: Total synthesis of (±)-pallambins C and D

Supplementary files

Article information

Article type
Communication
Submitted
16 Jun 2012
Accepted
05 Jul 2012
First published
06 Jul 2012

Chem. Commun., 2012,48, 8517-8519

Total synthesis of (±)-pallambins C and D

X. Xu, Z. Li, Y. Zhang, X. Peng and H. N. C. Wong, Chem. Commun., 2012, 48, 8517 DOI: 10.1039/C2CC34310J

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