Issue 87, 2012
From the journal:

Chemical Communications

Supramolecular metal displacement allows on-fluorescence analysis of manganese(ii) in living cells†

Francesca Gruppi,a   Jian Liang,a   Benjamin B. Bartelle,b   Maksim Royzen,a   Daniel H. Turnbullb  and  James W. Canary*a  

* Corresponding authors

a Department of Chemistry, New York University, New York, USA
E-mail: canary@nyu.edu
Fax: +1 212-995-4367
Tel: +1 212-998-8422

b Kimmel Center for Biology & Medicine at the Skirball Institute of Biomolecular Medicine, and Department of Radiology, New York University School of Medicine, New York, USA

Abstract

Due to the importance of Mn2+ ions in biological processes, it is of growing interest to develop protocols for analysis of Mn2+ uptake and distribution in cells. A supramolecular metal displacement assay can provide ratiometric fluorescence detection of Mn2+, allowing for quantitative and longitudinal analysis of Mn2+ uptake in living cells.

Graphical abstract: Supramolecular metal displacement allows on-fluorescence analysis of manganese(ii) in living cells

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Article information

DOI
https://doi.org/10.1039/C2CC34742C
Article type
Communication
Submitted
03 Jul 2012
Accepted
14 Sep 2012
First published
18 Sep 2012

Chem. Commun., 2012,48, 10778-10780

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Supramolecular metal displacement allows on-fluorescence analysis of manganese(II) in living cells

F. Gruppi, J. Liang, B. B. Bartelle, M. Royzen, D. H. Turnbull and J. W. Canary, Chem. Commun., 2012, 48, 10778 DOI: 10.1039/C2CC34742C

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