Issue 72, 2012
From the journal:

Chemical Communications

A human telomeric DNA-based chiral biosensor†

Lingyan Feng,a   Bailu Xu,a   Jinsong Ren,a   Chuanqi Zhaoa  and  Xiaogang Qu*a  

* Corresponding authors

a Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China
E-mail: xqu@ciac.jl.cn

Abstract

Here we report an electrochemical DNA (E-DNA) chiral sensor that can distinguish zinc-finger like metallo-supramolecular enantiomers based on human telomeric G-quadruplex formation specifically induced by one of the enantiomers. The assay is easy to operate and reusable with an enantioselective recognition ratio higher than 5.

Graphical abstract: A human telomeric DNA-based chiral biosensor

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC34776H
Article type
Communication
Submitted
04 Jul 2012
Accepted
19 Jul 2012
First published
19 Jul 2012

Chem. Commun., 2012,48, 9068-9070

Permissions

Request permissions

A human telomeric DNA-based chiral biosensor

L. Feng, B. Xu, J. Ren, C. Zhao and X. Qu, Chem. Commun., 2012, 48, 9068 DOI: 10.1039/C2CC34776H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements