Issue 82, 2012
From the journal:

Chemical Communications

Colorimetric detection of single-nucleotide polymorphisms with a real-time PCR-like sensitivity†

Wei Shen,a   Huimin Deng,a   Alan Kay Liang Teoa  and  Zhiqiang Gao*a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore
E-mail: chmgaoz@nus.edu.sg
Fax: +65-6779-1691
Tel: +65-6516-3887

Abstract

Coupling gold nanoparticle-based ligation to a ligation chain reaction enables colorimetric detection of single-nucleotide polymorphisms with a real-time PCR-like sensitivity. One mutant in 2000 copies of a wild-type gene can be detected in 20–100 pg of PCR-amplified genomic DNA samples.

Graphical abstract: Colorimetric detection of single-nucleotide polymorphisms with a real-time PCR-like sensitivity

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Article information

DOI
https://doi.org/10.1039/C2CC35070J
Article type
Communication
Submitted
13 Jun 2012
Accepted
28 Aug 2012
First published
29 Aug 2012

Chem. Commun., 2012,48, 10225-10227

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Colorimetric detection of single-nucleotide polymorphisms with a real-time PCR-like sensitivity

W. Shen, H. Deng, A. K. L. Teo and Z. Gao, Chem. Commun., 2012, 48, 10225 DOI: 10.1039/C2CC35070J

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