Issue 88, 2012

Highly enantioselective [4 + 2] cyclization of chloroaldehydes and 1-azadienes catalyzed by N-heterocyclic carbenes

Abstract

Highly functionalized dihydropyridinones were synthesized via the N-heterocyclic carbene-catalyzed enantioselective [4 + 2] annulation of α-chloroaldehydes and azadienes. Hydrogenation of the resulted dihydropyridinones afforded the corresponding piperidinones with high enantiopurity.

Graphical abstract: Highly enantioselective [4 + 2] cyclization of chloroaldehydes and 1-azadienes catalyzed by N-heterocyclic carbenes

Supplementary files

Article information

Article type
Communication
Submitted
21 Jul 2012
Accepted
14 Sep 2012
First published
14 Sep 2012

Chem. Commun., 2012,48, 10907-10909

Highly enantioselective [4 + 2] cyclization of chloroaldehydes and 1-azadienes catalyzed by N-heterocyclic carbenes

T. Jian, L. Sun and S. Ye, Chem. Commun., 2012, 48, 10907 DOI: 10.1039/C2CC35273G

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