Issue 88, 2012

Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin–nicotinamide cocrystal by solid-state NMR

Abstract

Two-dimensional 1H double-quantum and 14N–1H & 1H–13C heteronuclear magic-angle spinning (MAS) NMR spectra recorded at natural isotopic abundance identify specific intermolecular COOH⋯Narom and CHarom⋯O[double bond, length as m-dash]C hydrogen-bonding interactions in the solid-state structure of an indomethacin–nicotinamide cocrystal, thus additionally proving cocrystal formation.

Graphical abstract: Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin–nicotinamide cocrystal by solid-state NMR

Supplementary files

Article information

Article type
Communication
Submitted
22 Aug 2012
Accepted
19 Sep 2012
First published
21 Sep 2012

Chem. Commun., 2012,48, 10844-10846

Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin–nicotinamide cocrystal by solid-state NMR

K. Maruyoshi, D. Iuga, O. N. Antzutkin, A. Alhalaweh, S. P. Velaga and S. P. Brown, Chem. Commun., 2012, 48, 10844 DOI: 10.1039/C2CC36094B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements