Issue 92, 2012
From the journal:

Chemical Communications

Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation†‡

Mark D. Eddleston,a   Mihails Arhangelskis,a   Tomislav Friščićab  and  William Jones*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: wj10@cam.ac.uk
Tel: +44 (0)1223 336468

b Department of Chemistry, McGill University, H3A 0B8 Montreal, Canada
Tel: +1 514398-3959

Abstract

The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.

Graphical abstract: Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation

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Article information

DOI
https://doi.org/10.1039/C2CC36130B
Article type
Communication
Submitted
23 Aug 2012
Accepted
25 Sep 2012
First published
16 Oct 2012

Chem. Commun., 2012,48, 11340-11342

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Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation

M. D. Eddleston, M. Arhangelskis, T. Friščić and W. Jones, Chem. Commun., 2012, 48, 11340 DOI: 10.1039/C2CC36130B

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