Issue 89, 2012

Enzyme-regulated unmodified gold nanoparticle aggregation: a label free colorimetric assay for rapid and sensitive detection of adenosine deaminase activity and inhibition

Abstract

Based on enzyme-regulated unmodified gold nanoparticle aggregation, a visual and homogeneous assay of adenosine deaminase (ADA) activity without any other coupling enzymes, aptamers or additional modifications has been developed. The present strategy is simple, cost-effective, high throughput, selective and sensitive for ADA with a detection limit of 0.8227 U Lāˆ’1.

Graphical abstract: Enzyme-regulated unmodified gold nanoparticle aggregation: a label free colorimetric assay for rapid and sensitive detection of adenosine deaminase activity and inhibition

Supplementary files

Article information

Article type
Communication
Submitted
28 Aug 2012
Accepted
23 Sep 2012
First published
25 Sep 2012

Chem. Commun., 2012,48, 10996-10998

Enzyme-regulated unmodified gold nanoparticle aggregation: a label free colorimetric assay for rapid and sensitive detection of adenosine deaminase activity and inhibition

L. Zhang, J. Zhao, J. Jiang and R. Yu, Chem. Commun., 2012, 48, 10996 DOI: 10.1039/C2CC36240F

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