Issue 8, 2013

Copper-catalyzed C–N bond formation through C–H/N–H activation: a novel approach to the synthesis of multisubstituted ureas

Abstract

A copper-catalyzed cross-dehydrogenative coupling reaction that involves C–H activation of formamides and N–H activation of N-alkoxy amides has been developed. This protocol affords a novel approach to the synthesis of multisubstituted ureas under mild conditions.

Graphical abstract: Copper-catalyzed C–N bond formation through C–H/N–H activation: a novel approach to the synthesis of multisubstituted ureas

Supplementary files

Article information

Article type
Communication
Submitted
03 Sep 2012
Accepted
20 Nov 2012
First published
22 Nov 2012

Chem. Commun., 2013,49, 819-821

Copper-catalyzed C–N bond formation through C–H/N–H activation: a novel approach to the synthesis of multisubstituted ureas

H. Jiang, A. Lin, C. Zhu and Y. Cheng, Chem. Commun., 2013, 49, 819 DOI: 10.1039/C2CC36417D

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