Issue 99, 2012
From the journal:

Chemical Communications

A biocatalytic hydrogenation of carboxylic acids†

Yan Ni,ab   Peter-Leon Hagedoorn,*a   Jian-He Xu,b   Isabel W. C. E. Arendsa  and  Frank Hollmann*a  

* Corresponding authors

a Delft University of Technology, Department of Biotechnology, Julianalaan 136, 2628BL Delft, The Netherlands
E-mail: p.l.hagedoorn@tudelft.nl, f.hollmann@tudelft.nl
Fax: +31 152781415
Tel: +31 152781957

b East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, Shanghai 200237, People's Republic of China

Abstract

The hyperthermophile Pyrococcus furiosus catalyses the hydrogenation of a broad range of carboxylic acids selectively to the corresponding primary alcohols. Other functional groups such as isolated C[double bond, length as m-dash]C-double bonds are not touched. The chemoselectivity of the carboxylate reduction may be directed towards aldehydes by simple medium engineering.

Graphical abstract: A biocatalytic hydrogenation of carboxylic acids

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Article information

DOI
https://doi.org/10.1039/C2CC36479D
Article type
Communication
Submitted
05 Sep 2012
Accepted
01 Nov 2012
First published
02 Nov 2012

Chem. Commun., 2012,48, 12056-12058

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A biocatalytic hydrogenation of carboxylic acids

Y. Ni, P. Hagedoorn, J. Xu, I. W. C. E. Arends and F. Hollmann, Chem. Commun., 2012, 48, 12056 DOI: 10.1039/C2CC36479D

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