Issue 95, 2012
From the journal:

Chemical Communications

A convenient synthesis of anthranilic acids by Pd-catalyzed direct intermolecular ortho-C–H amidation of benzoic acids†

Ka-Ho Ng,a   Fo-Ning Nga  and  Wing-Yiu Yu*a  

* Corresponding authors

a State Key Laboratory for Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
E-mail: wing-yiu.yu@polyu.edu.hk
Fax: +852 2364 9932
Tel: +852 3400 8725

Abstract

An efficient method for synthesis of anthranilic acids by Pd-catalyzed ortho-C–H amidation of benzoic acids is disclosed. The amidation is proposed to proceed by carboxylate-assisted ortho-C–H palladation to form an arylpalladium(II) complex, followed by nitrene insertion to the Pd–C bond.

Graphical abstract: A convenient synthesis of anthranilic acids by Pd-catalyzed direct intermolecular ortho-C–H amidation of benzoic acids

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC36502B
Article type
Communication
Submitted
06 Sep 2012
Accepted
16 Oct 2012
First published
16 Oct 2012

Chem. Commun., 2012,48, 11680-11682

Permissions

Request permissions

A convenient synthesis of anthranilic acids by Pd-catalyzed direct intermolecular ortho-C–H amidation of benzoic acids

K. Ng, F. Ng and W. Yu, Chem. Commun., 2012, 48, 11680 DOI: 10.1039/C2CC36502B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements