Issue 23, 2013

Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study

Abstract

The development of a new class of surfactants for membrane protein manipulation, “GNG amphiphiles”, is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

Graphical abstract: Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
20 Sep 2012
Accepted
02 Nov 2012
First published
05 Nov 2012

Chem. Commun., 2013,49, 2287-2289

Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study

P. S. Chae, R. R. Rana, K. Gotfryd, S. G. F. Rasmussen, A. C. Kruse, K. H. Cho, S. Capaldi, E. Carlsson, B. Kobilka, C. J. Loland, U. Gether, S. Banerjee, B. Byrne, J. K. Lee and S. H. Gellman, Chem. Commun., 2013, 49, 2287 DOI: 10.1039/C2CC36844G

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