Issue 100, 2012

DNA surface coating of calixarene-based nanoparticles: a sequence-dependent binding mechanism

Abstract

An amphiphilic calix[4]arene derivative bearing four guanidino moieties at the upper rim and four dodecyl chains at the lower rim was shown to form stable solid lipid nanoparticles (SLNs) in water. The study of the interactions of these cationic SLNs with DNA revealed a sequence-dependent groove binding mechanism.

Graphical abstract: DNA surface coating of calixarene-based nanoparticles: a sequence-dependent binding mechanism

Supplementary files

Article information

Article type
Communication
Submitted
20 Sep 2012
Accepted
19 Oct 2012
First published
23 Oct 2012

Chem. Commun., 2012,48, 12186-12188

DNA surface coating of calixarene-based nanoparticles: a sequence-dependent binding mechanism

V. Rullaud, M. Siragusa, A. Cumbo, D. Gygax and P. Shahgaldian, Chem. Commun., 2012, 48, 12186 DOI: 10.1039/C2CC36859E

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