Issue 99, 2012
From the journal:

Chemical Communications

DNA-based delivery vehicles: pH-controlled disassembly and cargo release†

Jung-Won Keum‡a  and  Harry Bermudez*b  

* Corresponding authors

a Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA

b Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA, USA
E-mail: bermudez@polysci.umass.edu
Fax: +1 413 545 0082
Tel: +1 413 577 1413

Abstract

Non-Watson–Crick base pairing provides an in situ approach for actuation of DNA nanostructures through responses to solution conditions. Here we demonstrate this concept by using physiologically-relevant changes in pH to regulate DNA pyramid assembly/disassembly and to control the release of protein cargo.

Graphical abstract: DNA-based delivery vehicles: pH-controlled disassembly and cargo release

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Article information

DOI
https://doi.org/10.1039/C2CC37471D
Article type
Communication
Submitted
12 Oct 2012
Accepted
06 Nov 2012
First published
07 Nov 2012

Chem. Commun., 2012,48, 12118-12120

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DNA-based delivery vehicles: pH-controlled disassembly and cargo release

J. Keum and H. Bermudez, Chem. Commun., 2012, 48, 12118 DOI: 10.1039/C2CC37471D

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