Issue 15, 2013

Palladium catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol

Abstract

We report efficient Pd-catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes as the basis of a general entry to α,α-disubstituted pyrrolidine derivatives. We also demonstrate that catalytic asymmetric variants of this chemistry are feasible by employing a suitable chiral ligand.

Graphical abstract: Palladium catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol

Supplementary files

Article information

Article type
Communication
Submitted
14 Dec 2012
Accepted
04 Jan 2013
First published
04 Jan 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 1521-1523

Palladium catalyzed cyclizations of oximeesters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol

A. Faulkner, J. S. Scott and J. F. Bower, Chem. Commun., 2013, 49, 1521 DOI: 10.1039/C2CC38944D

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