Issue 7, 2012
From the journal:

CrystEngComm

Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs†

David R. Weyna,a   Miranda L. Cheney,a   Ning Shan,*a   Mazen Hanna,a   Łukasz Wojtasb  and  Michael J. Zaworotko*b  

* Corresponding authors

a Thar Pharmaceuticals Inc, 3802 Spectrum Boulevard, Suite 120, Tampa, Florida, USA
E-mail: nshan@tharpharma.com
Tel: +1-813-978-3980

b Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, CHE205, Tampa, Florida, USA
E-mail: xtal@usf.edu

Abstract

Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid have been prepared and characterized. The crystal packing observed in the three resulting cocrystals reveals that tadalafil molecules form persistent hydrogen-bonded chains which accept additional hydrogen bonds from the OH moieties of the respective coformers.

Graphical abstract: Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs

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Article information

DOI
https://doi.org/10.1039/C2CE06574F
Article type
Communication
Submitted
23 Nov 2011
Accepted
15 Dec 2011
First published
23 Dec 2011

CrystEngComm, 2012,14, 2377-2380

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Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs

D. R. Weyna, M. L. Cheney, N. Shan, M. Hanna, Ł. Wojtas and M. J. Zaworotko, CrystEngComm, 2012, 14, 2377 DOI: 10.1039/C2CE06574F

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