Issue 23, 2012

Polymorphism in an API ionic liquid: ethambutol dibenzoate trimorphs

Abstract

Three polymorphs of the dibenzoate salt of the anti-tubercular drug ethambutol (EDB) were crystallized as ionic liquids (m.p. < 100 °C) and characterized by diffraction (PXRD), thermal (DSC) and spectroscopy (IR, Raman, ss-NMR) techniques. Their stability relationships were established by DSC and VT-PXRD: EDB form 1 is the most stable, followed by form 3, and form 2 is the least stable at room temperature (25 °C); form 3 is the most stable, then form 1, and form 2 is the least stable at high temperature (90 °C).

Graphical abstract: Polymorphism in an API ionic liquid: ethambutol dibenzoate trimorphs

Supplementary files

Article information

Article type
Communication
Submitted
28 May 2012
Accepted
12 Jul 2012
First published
12 Jul 2012

CrystEngComm, 2012,14, 7840-7843

Polymorphism in an API ionic liquid: ethambutol dibenzoate trimorphs

S. Cherukuvada and A. Nangia, CrystEngComm, 2012, 14, 7840 DOI: 10.1039/C2CE25842K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements