Issue 3, 2013

Catalytic enantioselective [4 + 2]-cycloaddition: a strategy to access aza-hexacycles

Abstract

The aza-Diels Alder reaction has become one of the most widely used synthetic tools for the preparation of N-containing 6-membered heterocycles. Numerous important developments have been reported to render this reaction catalytic and enantioselective. This tutorial review highlights strategies and recent advances to achieve high efficiency and selectivity through the use of organocatalysts and transition metal complexes, allowing also the extension of this transformation substrate scope.

Graphical abstract: Catalytic enantioselective [4 + 2]-cycloaddition: a strategy to access aza-hexacycles

Article information

Article type
Tutorial Review
Submitted
04 Sep 2012
First published
21 Nov 2012

Chem. Soc. Rev., 2013,42, 902-923

Catalytic enantioselective [4 + 2]-cycloaddition: a strategy to access aza-hexacycles

G. Masson, C. Lalli, M. Benohoud and G. Dagousset, Chem. Soc. Rev., 2013, 42, 902 DOI: 10.1039/C2CS35370A

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