Issue 13, 2012

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbeneligands

Abstract

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

Graphical abstract: Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

Article information

Article type
Paper
Submitted
12 Dec 2011
Accepted
05 Jan 2012
First published
06 Jan 2012

Dalton Trans., 2012,41, 3720-3725

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

D. C. F. Monteiro, R. M. Phillips, B. D. Crossley, J. Fielden and C. E. Willans, Dalton Trans., 2012, 41, 3720 DOI: 10.1039/C2DT12399A

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