Issue 13, 2012

Coordination bonding based pH-responsive albumin nanoparticles for anticancer drug delivery

Abstract

Zn-loaded bovine serum albumin nanoparticles (Zn–BSA nanoparticles) were prepared and used as carriers for pH-responsive anticancer drug delivery. Zinc was introduced into this system to increase the stability of the BSA nanoparticles and to load the anticancer drug based on the coordination bonding formation of Zn–BSA and Zn–drug molecules, respectively. The cleavage of either the “Zn–BSA” or the “Zn–drug” coordination bonding, in response to pH, would result in the release of the drug under designated pH conditions. The nanoparticles were spherical with diameters of 50–60 nm and narrow size distribution. Mitoxantrone (MX) was chosen as the model drug to study the release behavior and the inhibitory efficacy against tumor cells. In vitro release behavior of MX loaded Zn–BSA nanoparticles (MX–Zn–BSA nanoparticles) showed a fine pH-responsiveness. The release amount at pH 5.0 was close to 80%, while the cumulative release amount at pH 7.4 was less than 6% within 24 h. The blank Zn–BSA nanoparticles were of low cytotoxicity, while a high cytotoxic activity of MX–Zn–BSA nanoparticles against MCF-7 cells was demonstrated by in vitro cell assays.

Graphical abstract: Coordination bonding based pH-responsive albumin nanoparticles for anticancer drug delivery

Supplementary files

Article information

Article type
Paper
Submitted
31 Jan 2012
Accepted
02 Feb 2012
First published
03 Feb 2012

Dalton Trans., 2012,41, 3714-3719

Coordination bonding based pH-responsive albumin nanoparticles for anticancer drug delivery

C. Li, L. Xing and S. Che, Dalton Trans., 2012, 41, 3714 DOI: 10.1039/C2DT30226H

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