Issue 23, 2012

Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

Abstract

Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.

Graphical abstract: Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

Supplementary files

Article information

Article type
Communication
Submitted
16 Feb 2012
Accepted
24 Apr 2012
First published
24 Apr 2012

Dalton Trans., 2012,41, 6906-6909

Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

C. Sun, C. Qin, X. Wang, G. Yang, K. Shao, Y. Lan, Z. Su, P. Huang, C. Wang and E. Wang, Dalton Trans., 2012, 41, 6906 DOI: 10.1039/C2DT30357D

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