New half sandwich Ru(ii) coordination compounds for anticancer activity

Abstract

With the aim of expanding the structure–activity relationship investigation, the series of Ru(II) half sandwich coordination compounds of the type [Ru([9]aneS3)(chel)(L)]ⁿ⁺ previously described by us (where [9]aneS3 is the neutral face-capping ligand 1,4,7-trithiacyclononane, chel is a neutral or anonic chelating ligand, L = Cl⁻ or dmso-S, n = 0–2) was extended to 1,4,7-triazacyclononane ([9]aneN3). In addition, new neutral N–N, and anionic N–O and O–O chelating ligands, i.e. dach (trans-1,2-diaminocyclohexane), pic⁻ (picolinate), and acac⁻ (acetylacetonate), were investigated in combination with both [9]aneS3 and [9]aneN3. Overall, ten new half-sandwich complexes were prepared and fully characterized and their chemical behaviour in aqueous solution was established. The single-crystal X-ray structures of eight of them, including the versatile precursor [Ru([9]aneN3)(dmso-S)₂Cl]Cl (9), were also determined. The results of in vitro antiproliferative tests performed on selected compounds against MDA-MB-231 human mammary carcinoma cells confirmed that, in this series, only compounds that hydrolyse the monodentate ligand at a reasonable rate show moderate activity, provided that the chelate ligand is a hydrogen bond donor.