Rigid Mn(II) chelate as efficient MRI contrast agent for vascular imaging

Hongying Su; Changqiang Wu; Jiang Zhu; Tianxin Miao; Dan Wang; Chunchao Xia; Xuna Zhao; Qiyong Gong; Bin Song; Hua Ai

doi:10.1039/C2DT31696J

Rigid Mn(ii) chelate as efficient MRI contrast agent for vascular imaging†

Hongying Su,‡^a Changqiang Wu,‡^a Jiang Zhu,*^b Tianxin Miao,^a Dan Wang,^a Chunchao Xia,^c Xuna Zhao,^d Qiyong Gong,^b Bin Song^c and Hua Ai*^ac

Author affiliations

* Corresponding authors

^a National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P. R. China
E-mail: huaai@scu.edu.cn
Fax: +86-28-85413991
Tel: +86-28-85413991

^b Sichuan Key laboratory of Medical Imaging, North Sichuan Medical College, Nanchong 637007, China
E-mail: zhujiang312@hotmail.com
Tel: +86-817-2802315

^c Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China

^d Philips Healthcare, Beijing 100020, China

Abstract

The aza-semi-crown pentadentate ligand rigidified by pyridine and piperidine rings was designed and synthesized. It can react with Mn(II) in water to form complex with improved longitudinal relaxivity, leading to efficient signal intensity enhancement of vascular vessels under a clinical magnetic resonance imaging scanner.

Dalton Transactions

Rigid Mn(ii) chelate as efficient MRI contrast agent for vascular imaging†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Rigid Mn(II) chelate as efficient MRI contrast agent for vascular imaging

Social activity

Search articles by author

Spotlight

Advertisements