Issue 4, 2012
From the journal:

Green Chemistry

Silica-supported 5-(pyrrolidin-2-yl)tetrazole: development of organocatalytic processes from batch to continuous-flow conditions†

Olga Bortolini,a   Lorenzo Caciolli,a   Alberto Cavazzini,*b   Valentina Costa,b   Roberto Greco,b   Alessandro Massi*a  and  Luisa Pastib  

* Corresponding authors

a Dipartimento di Chimica, Laboratorio di Chimica Organica, Università di Ferrara, Via L. Borsari 46, I-44121 Ferrara, Italy
E-mail: alessandro.massi@unife.it
Fax: +39 0532 455183
Tel: +39 0532 455183

b Dipartimento di Chimica, Laboratorio di Chimica Analitica, Università di Ferrara, Italy
E-mail: alberto.cavazzini@unife.it
Fax: +39 0532 455133
Tel: +39 0532 455133

Abstract

5-(Pyrrolidin-2-yl)tetrazole functionalized silica prepared by photoinduced thiol–ene coupling is packed into a short stainless steel column. The resulting packed-bed microreactor is conveniently heated to perform environmentally benign continuous-flow aldol reactions with good stereoselectivities, complete conversion efficiencies, and long term stability of the packing material.

Graphical abstract: Silica-supported 5-(pyrrolidin-2-yl)tetrazole: development of organocatalytic processes from batch to continuous-flow conditions

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Article information

DOI
https://doi.org/10.1039/C2GC16673A
Article type
Paper
Submitted
27 Dec 2011
Accepted
19 Jan 2012
First published
14 Feb 2012

Green Chem., 2012,14, 992-1000

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Silica-supported 5-(pyrrolidin-2-yl)tetrazole: development of organocatalytic processes from batch to continuous-flow conditions

O. Bortolini, L. Caciolli, A. Cavazzini, V. Costa, R. Greco, A. Massi and L. Pasti, Green Chem., 2012, 14, 992 DOI: 10.1039/C2GC16673A

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