Issue 37, 2012
From the journal:

Journal of Materials Chemistry

A unique polymeric nano-carrier for anti-tuberculosis therapy†

Shivshankar R. Mane,a   Vijayakameswara Rao N,a   Koushik Chatterjee,a   Himadri Dinda,a   Soma Nag,b   Abhinoy Kishore,b   Jayasri Das Sarma*b  and  Raja Shunmugam*a  

* Corresponding authors

a Polymer Research Centre, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata (IISER K), India
E-mail: sraja@iiserkol.ac.in

b Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata (IISER K), India

Abstract

A nano-carrier made of a norbornene derived isoniazid copolymer is designed. In vitro cytotoxicity assay and renal clearance analysis clearly indicate that the newly designed nano-carrier is biocompatible in nature. This nano-carrier with a hydrazone linker is shown to be a promising reservoir with excellent performance for an efficient drug delivery system. Moreover, the system also offers an effective strategy and new modalities for the development of TB therapy.

Graphical abstract: A unique polymeric nano-carrier for anti-tuberculosis therapy

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Article information

DOI
https://doi.org/10.1039/C2JM33860B
Article type
Communication
Submitted
15 Jun 2012
Accepted
02 Aug 2012
First published
06 Aug 2012

J. Mater. Chem., 2012,22, 19639-19642

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A unique polymeric nano-carrier for anti-tuberculosis therapy

S. R. Mane, V. Rao N, K. Chatterjee, H. Dinda, S. Nag, A. Kishore, J. D. Sarma and R. Shunmugam, J. Mater. Chem., 2012, 22, 19639 DOI: 10.1039/C2JM33860B

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