Issue 9, 2012

Walking nanothermometers: spatiotemporal temperature measurement of transported acidic organelles in single living cells

Abstract

We fabricated fluorescent nanoparticles which monitor temperature changes without sensitivity to pH (4–10) and ionic strength (0–500 mM). The nanothermometers spontaneously enter living HeLa cells via endocytosis, enclosed in acidic organelles, i.e., endosome/lysosome, and then transported along microtubules in a temperature-dependent manner, working as “walking nanothermometers”.

Graphical abstract: Walking nanothermometers: spatiotemporal temperature measurement of transported acidic organelles in single living cells

Supplementary files

Article information

Article type
Communication
Submitted
04 Jan 2012
Accepted
05 Mar 2012
First published
08 Mar 2012

Lab Chip, 2012,12, 1591-1593

Walking nanothermometers: spatiotemporal temperature measurement of transported acidic organelles in single living cells

K. Oyama, M. Takabayashi, Y. Takei, S. Arai, S. Takeoka, S. Ishiwata and M. Suzuki, Lab Chip, 2012, 12, 1591 DOI: 10.1039/C2LC00014H

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