Issue 3, 2013

Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

Abstract

Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results.

Graphical abstract: Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

Supplementary files

Article information

Article type
Paper
Submitted
11 Oct 2012
Accepted
25 Oct 2012
First published
26 Oct 2012

Lab Chip, 2013,13, 386-390

Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

C. Parolo, M. Medina-Sánchez, A. de la Escosura-Muñiz and A. Merkoçi, Lab Chip, 2013, 13, 386 DOI: 10.1039/C2LC41144J

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