Issue 4, 2012
From the journal:

MedChemComm

Synthesis and biological activities of ferrocenyl derivatives of paclitaxel†

Damian Plażuk,*a   Anna Wieczorek,a   Andrzej Błaużb  and  Błażej Rychlikb  

* Corresponding authors

a Department of Organic Chemistry, Faculty of Chemistry, University of Łódź, Tamka 12, 91-403 Łódź, Poland
E-mail: damplaz@uni.lodz.pl
Fax: +48 42 6786583
Tel: +48 42 6355760

b Cytometry Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Łódź, 12/16 Banacha St., 90-237 Łódź, Poland

Abstract

A series of ferrocenyl taxoids were prepared by acylation of paclitaxel and docetaxel with ferrocenecarboxylic acid and 3-ferrocenoylpropionic acid in good yield. The prepared compounds showed high activities against multidrug-resistant colon adenocarcinoma cell lines.

Graphical abstract: Synthesis and biological activities of ferrocenyl derivatives of paclitaxel

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Article information

DOI
https://doi.org/10.1039/C2MD00315E
Article type
Concise Article
Submitted
22 Dec 2011
Accepted
09 Feb 2012
First published
10 Feb 2012

Med. Chem. Commun., 2012,3, 498-501

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Synthesis and biological activities of ferrocenyl derivatives of paclitaxel

D. Plażuk, A. Wieczorek, A. Błauż and B. Rychlik, Med. Chem. Commun., 2012, 3, 498 DOI: 10.1039/C2MD00315E

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