Issue 2, 2013
From the journal:

MedChemComm

3,3-Dimethyl-1H-pyrrolo[3,2-g]quinolin-2(3H)-one derivatives as novel Raf kinase inhibitors

Yanyang Li,ab   Xiangfei Shi,b   Ning Xie,bc   Yanjin Zhaob  and  Shuxin Li*bc  

* Corresponding authors

a Chinese PLA Postgraduate Medical School, Beijing 100853, China
E-mail: yysymc@163.com
Fax: +86 10 6821 4653
Tel: +86 10 6693 2289

b Institute of Radiation and Irradiation Medicine, Academy of Military Medical Science, Beijing 100850, China
E-mail: lisx28@163.com
Fax: +86 10 6821 4653
Tel: +86 10 6693 2289

c Department of Medicinal Chemistry, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China
E-mail: xiening575@163.com
Fax: +86 10 6821 4653
Tel: +86 10 6693 2289

Abstract

A series of quinoline derivatives were designed and synthesized as tyrosine kinase inhibitors. Exploration of the structure–activity relationships resulted in compounds that are potent in vitro. In addition, compound 10f was found to be a potent and selective Raf kinase inhibitor.

Graphical abstract: 3,3-Dimethyl-1H-pyrrolo[3,2-g]quinolin-2(3H)-one derivatives as novel Raf kinase inhibitors

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Article information

DOI
https://doi.org/10.1039/C2MD20275A
Article type
Concise Article
Submitted
13 Sep 2012
Accepted
13 Nov 2012
First published
10 Dec 2012

Med. Chem. Commun., 2013,4, 367-370

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3,3-Dimethyl-1H-pyrrolo[3,2-g]quinolin-2(3H)-one derivatives as novel Raf kinase inhibitors

Y. Li, X. Shi, N. Xie, Y. Zhao and S. Li, Med. Chem. Commun., 2013, 4, 367 DOI: 10.1039/C2MD20275A

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