Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives

Abstract

Novel guanidinium and urea derivatives of 1-deoxynojirimycin were prepared using a concise synthetic protocol and tested against a panel of glycosidases for their inhibitory properties. Potent and selective inhibition was observed with both classes of compounds. Further investigation involving an expanded series of N^G-substituted guanidinium deoxynojirimycin analogues revealed distinct inhibitory profiles in the inhibition of the glycosidases tested.