Issue 4, 2012
From the journal:

Natural Product Reports

Phenazines and cancer

A. Cimmino,†a   A. Evidente,†a   V. Mathieu,b   A. Andolfi,a   F. Lefranc,bc   A. Kornienkod  and  R. Kiss*b  

* Corresponding authors

a Dipartimento di Scienze del Suolo, della Pianta, dell'Ambiente e delle Produzioni Animali, Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy

b Laboratoire de Toxicologie, Faculté de Pharmacie and Université Libre de Bruxelles (ULB), Campus de la Plaine CP205/1, Boulevard du Triomphe, 1050 Brussels, Belgium
E-mail: rkiss@ulb.ac.be
Tel: +32 477 62 20 83

c Service de Neurochirurgie, Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium

d Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico, USA

Abstract

Covering: 2000 to 2011

Phenazines are a large group of natural and synthesised nitrogen-containing heterocycles, including more than 100 different compounds of natural origin and over 6000 synthetic compounds. Many of these compounds have been investigated as potential anti-cancer agents. Despite a large number of research publications, no recent attempt to summarise and critically evaluate the experimental findings relating to the anti-cancer activity of this class of compounds has been made. The present review fills this gap in the literature and discusses both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds.

Graphical abstract: Phenazines and cancer

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Article information

DOI
https://doi.org/10.1039/C2NP00079B
Article type
Review Article
Submitted
13 Oct 2011
First published
15 Feb 2012

Nat. Prod. Rep., 2012,29, 487-501

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Phenazines and cancer

A. Cimmino, A. Evidente, V. Mathieu, A. Andolfi, F. Lefranc, A. Kornienko and R. Kiss, Nat. Prod. Rep., 2012, 29, 487 DOI: 10.1039/C2NP00079B

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