Issue 23, 2012
From the journal:

Nanoscale

Graphene oxide strongly inhibits amyloid beta fibrillation†

Morteza Mahmoudi,‡*ab   Omid Akhavan,*cd   Mahdi Ghavami,a   Farhad Rezaeeef  and  Seyyed Mohammad Amin Ghiasic  

* Corresponding authors

a Department of Nanotechnology, Faculty of Pharmacy Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran
E-mail: mahmoudi-m@tums.ac.ir
Web: www.biospion.com
Fax: +98 21-66492595

b Nanotechnology Research Center, Faculty of Pharmacy Tehran, University of Medical Sciences Tehran, P.O. Box 14155-6451, Tehran, Iran

c Department of Physics, Sharif University of Technology, P.O. Box 11155–9161, Tehran, Iran

d Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 14588–89694, Tehran, Iran
E-mail: oakhavan@sharif.edu
Fax: +98 21-66022711

e Department of Cell Biology, Medical Biomics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

f Department for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Abstract

Since amyloid beta fibrillation (AβF) plays an important role in the development of neurodegenerative diseases, we investigated the effect of graphene oxide (GO) and their protein-coated surfaces on the kinetics of Aβ fibrillation in the aqueous solution. We showed that GO and their protein-covered surfaces delay the AβF process via adsorption of amyloid monomers. Also, the large available surface of GO sheets can delay the AβF process by adsorption of amyloid monomers. The inhibitory effect of the GO sheet was increased when we increase the concentration from 10% (in vitro; stimulated media) to 100% (in vivo; stimulated media). Conclusion: our results revealed that GO and their surface proteins inhibit AβF by decreasing the kinetic reaction.

Graphical abstract: Graphene oxide strongly inhibits amyloid beta fibrillation

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Article information

DOI
https://doi.org/10.1039/C2NR31657A
Article type
Communication
Submitted
28 Jun 2012
Accepted
24 Sep 2012
First published
02 Oct 2012

Nanoscale, 2012,4, 7322-7325

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Graphene oxide strongly inhibits amyloid beta fibrillation

M. Mahmoudi, O. Akhavan, M. Ghavami, F. Rezaee and S. M. A. Ghiasi, Nanoscale, 2012, 4, 7322 DOI: 10.1039/C2NR31657A

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