Issue 45, 2012
From the journal:

Organic & Biomolecular Chemistry

Synthesis of 4,6-disubstituted 2-(4-morpholinyl)pyrimidines by cross-coupling reactions using triorganoindium compounds†

M. Montserrat Martínez,*a   Cristina Pérez-Caaveiro,a   Miguel Peña-López,a   Luis A. Sarandesesa  and  José Pérez Sestelo*a  

* Corresponding authors

a Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain
E-mail: sestelo@udc.es, mmartinezc@udc.es
Fax: +34 981 167 065
Tel: +34 981 167 000

Abstract

4,6-Disubstituted-2-(4-morpholinyl)pyrimidines, an important class of bioactive compounds, have been synthesized from 4,6-dichloro-2-(4-morpholinyl)pyrimidine by selective and sequential palladium-catalyzed cross-coupling reactions using triorganoindium reagents. This methodology, being efficient and versatile, allowed the synthesis of a variety of non-symmetrical pyrimidines functionalized at C-4 and C-6 positions.

Graphical abstract: Synthesis of 4,6-disubstituted 2-(4-morpholinyl)pyrimidines by cross-coupling reactions using triorganoindium compounds

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Article information

DOI
https://doi.org/10.1039/C2OB26398J
Article type
Paper
Submitted
18 Jul 2012
Accepted
01 Oct 2012
First published
02 Oct 2012

Org. Biomol. Chem., 2012,10, 9045-9051

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Synthesis of 4,6-disubstituted 2-(4-morpholinyl)pyrimidines by cross-coupling reactions using triorganoindium compounds

M. M. Martínez, C. Pérez-Caaveiro, M. Peña-López, L. A. Sarandeses and J. Pérez Sestelo, Org. Biomol. Chem., 2012, 10, 9045 DOI: 10.1039/C2OB26398J

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