Issue 45, 2012

Efficient synthesis of thieno[3,2-b:4,5-b′]diindoles and benzothieno[3,2-b]indoles by Pd-catalyzed site-selective C–C and C–N coupling reactions

Abstract

Heteroacenes (thieno[3,2-b:4,5-b′]diindoles and benzothieno[3,2-b]indoles) were efficiently synthesized from tetrabromothiophene and 2,3-dibromobenzothiophene in two steps, respectively. In the first step, a site-selective Pd-catalyzed C–C coupling is carried out, followed by a two-fold C–N coupling with aromatic and aliphatic amines.

Graphical abstract: Efficient synthesis of thieno[3,2-b:4,5-b′]diindoles and benzothieno[3,2-b]indoles by Pd-catalyzed site-selective C–C and C–N coupling reactions

Supplementary files

Article information

Article type
Paper
Submitted
30 Jul 2012
Accepted
21 Sep 2012
First published
26 Sep 2012

Org. Biomol. Chem., 2012,10, 9041-9044

Efficient synthesis of thieno[3,2-b:4,5-b′]diindoles and benzothieno[3,2-b]indoles by Pd-catalyzed site-selective C–C and C–N coupling reactions

T. Q. Hung, T. T. Dang, A. Villinger, T. V. Sung and P. Langer, Org. Biomol. Chem., 2012, 10, 9041 DOI: 10.1039/C2OB26489G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements