Rhodium(ii) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3′-bioxindoles

Abstract

The 3,3′-bioxindole derivatives were constructed in a single step via an efficient Rh₂(OAc)₄ catalyzed reaction of diazoacetamides with isatins. This novel method provides an alternative pathway towards 3-hydroxy-3,3′-bioxindoles in good yield (up to 78%) with high diastereoselectivity (up to 95 : 5).