Issue 10, 2012
From the journal:

Polymer Chemistry

PolyPEGylated nanodiamond for intracellular delivery of a chemotherapeutic drug†

Xiaoyong Zhang,a   Shiqi Wang,a   Changkui Fu,a   Lin Feng,a   Yan Ji,a   Lei Tao,*a   Shuxi Lia  and  Yen Wei*ab  

* Corresponding authors

a Department of Chemistry, Tsinghua University, Beijing, P. R. China
E-mail: leitao@mail.tsinghua.edu.cn, weiyen@tsinghua.edu.cn

b Key Lab of Organic Optoelectronic & Molecular Engineering of Ministry of Education, Tsinghua University, Beijing, P. R. China

Abstract

Water dispersible and biocompatible polyPEGylated ND nanoparticles were prepared via surface-initiated atom transfer radical polymerization. Cell internalization study reveals that ND nanoparticles facilitate the transport of doxorubicin hydrochloride into A549 cells, indicating their potential applications in cancer therapy.

Graphical abstract: PolyPEGylated nanodiamond for intracellular delivery of a chemotherapeutic drug

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Article information

DOI
https://doi.org/10.1039/C2PY20457F
Article type
Communication
Submitted
09 May 2012
Accepted
20 Jul 2012
First published
25 Jul 2012

Polym. Chem., 2012,3, 2716-2719

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PolyPEGylated nanodiamond for intracellular delivery of a chemotherapeutic drug

X. Zhang, S. Wang, C. Fu, L. Feng, Y. Ji, L. Tao, S. Li and Y. Wei, Polym. Chem., 2012, 3, 2716 DOI: 10.1039/C2PY20457F

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