Issue 10, 2012
From the journal:

Polymer Chemistry

pH-switchable polymer nanostructures for controlled release†

Kay E. B. Doncom,a   Claire F. Hansell,a   Patrick Theatob  and  Rachel K. O'Reilly*a  

* Corresponding authors

a University of Warwick, Department of Chemistry, Gibbet Hill Road, Coventry, UK
E-mail: Rachel.OReilly@warwick.ac.uk

b Institute for Technical and Macromolecular Chemistry, University of Hamburg, Bundesstrasse 45, Hamburg, Germany

Abstract

A diblock copolymer consisting of poly(methyl acrylate) (PMA) and poly(pentafluorophenyl acrylate) (PPFPA) was synthesized by RAFT polymerization methods. The PPFPA block was then substituted with N,N-diisopropylethylenediamine and the end group modified with one of two hydrophilic groups to form pH-responsive copolymers. The self-assembly properties of these polymers were investigated and shown by TEM and DLS to form micelles at acidic pH and vesicles at basic pH. The encapsulation and controlled release of a hydrophilic dye molecule, Rhodamine B, was demonstrated using fluorescence spectroscopy.

Graphical abstract: pH-switchable polymer nanostructures for controlled release

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Article information

DOI
https://doi.org/10.1039/C2PY20545A
Article type
Paper
Submitted
20 Jul 2012
Accepted
08 Aug 2012
First published
09 Aug 2012

Polym. Chem., 2012,3, 3007-3015

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pH-switchable polymer nanostructures for controlled release

K. E. B. Doncom, C. F. Hansell, P. Theato and R. K. O'Reilly, Polym. Chem., 2012, 3, 3007 DOI: 10.1039/C2PY20545A

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