Issue 14, 2012

Copper-catalysed addition of α-alkyl azaarenes to ethyl glyoxylatevia direct C(sp3)–H activation

Abstract

A novel protocol for the copper-catalysed direct C(sp3)–H bond functionalisation of 2-alkyl azaarenes to C[double bond, length as m-dash]O double bonds has been developed, which expands the scope of C(sp3)–H bond activation reactions and provides new access to medicinally important azaarene derivatives.

Graphical abstract: Copper-catalysed addition of α-alkyl azaarenes to ethyl glyoxylate via direct C(sp3)–H activation

Supplementary files

Article information

Article type
Communication
Submitted
04 Apr 2012
Accepted
09 May 2012
First published
14 May 2012

RSC Adv., 2012,2, 5968-5971

Copper-catalysed addition of α-alkyl azaarenes to ethyl glyoxylate via direct C(sp3)–H activation

J. Jin, H. Niu, G. Qu, H. Guo and J. S. Fossey, RSC Adv., 2012, 2, 5968 DOI: 10.1039/C2RA20627G

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