Palladium catalysed regioselective arylation of indoles, benzofuran and benzothiophene with aryldiazonium salts

Abstract

Aryldiazonium tetrafluoroborates have been successfully employed in the direct and regioselective arylation of heteroaromatics such as indole, benzofuran and benzothiophene. The cationic aryl palladium intermediates derived from the aryldiazonium salts act as effective electrophiles in the process. These arylating reactions display operational simplicity and provide the arylated heterocycles regioselectively in moderate to excellent yields.