Discovery of potent, novel antibacterial hybrid conjugates from 4-aminoquinoline and 1,3,5-triazine: design, synthesis and antibacterial evaluation

Abstract

A series of hybrid 4-aminoquinoline-1,3,5-triazine conjugates 7a–g were synthesized and evaluated for their in vitro antibacterial activity against several Gram-positive and Gram-negative microorganisms. The entire set of target compounds displayed potent to excellent activity against human disease causing pathogens with reference to Levofloxacin as a standard drug.