Issue 10, 2012
From the journal:

Chemical Science

A nanocrystal-based ratiometric pH sensor for natural pH ranges†

Rebecca C. Somers,a   Ryan M. Lanning,b   Preston T. Snee,‡a   Andrew B. Greytak,§a   Rakesh K. Jain,b   Moungi G. Bawendi*a  and  Daniel G. Nocera*a  

* Corresponding authors

a Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, USA
E-mail: nocera@mit.edu, mgb@mit.edu

b Edwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA 02114, USA
E-mail: jain@steele.mgh.harvard.edu

Abstract

A ratiometric fluorescent pH sensor based on CdSe/CdZnS nanocrystal quantum dots (NCs) has been designed for biological pH ranges. The construct is formed from the conjugation of a pH dye (SNARF) to NCs coated with a poly(amido amine) (PAMAM) dendrimer. The sensor exhibits a well-resolved ratio response at pH values between 6 and 8 under linear or two-photon excitation, and in the presence of a 4% bovine serum albumin (BSA) solution.

Graphical abstract: A nanocrystal-based ratiometric pH sensor for natural pH ranges

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Article information

DOI
https://doi.org/10.1039/C2SC20212C
Article type
Edge Article
Submitted
21 Feb 2012
Accepted
22 Jun 2012
First published
26 Jun 2012

Chem. Sci., 2012,3, 2980-2985

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A nanocrystal-based ratiometric pH sensor for natural pH ranges

R. C. Somers, R. M. Lanning, P. T. Snee, A. B. Greytak, R. K. Jain, M. G. Bawendi and D. G. Nocera, Chem. Sci., 2012, 3, 2980 DOI: 10.1039/C2SC20212C

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