Issue 10, 2012
From the journal:

Chemical Science

A fluorescent probe for rapid detection of hydrogen sulfide in blood plasma and brain tissues in mice†

Yong Qian,‡a   Ling Zhang,‡ab   Shuting Ding,a   Xin Deng,c   Chuan He,c   Xi Emily Zheng,a   Hai-Liang Zhua  and  Jing Zhao*a  

* Corresponding authors

a Institute of Chemistry and Biomedical Sciences, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, P. R. China
E-mail: jingzhao@nju.edu.cn

b School of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, 221002, P. R. China

c Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois, 60637, USA

Abstract

We describe the design, synthesis and application of a sensitive, selective, and fast fluorescent probe for H2S detection. A linear relationship between emission intensity and sulfide concentration was observed in biological bovine plasma systems. With this probe, we were able to estimate the sulfide concentration in mouse blood plasma and brain tissues.

Graphical abstract: A fluorescent probe for rapid detection of hydrogen sulfide in blood plasma and brain tissues in mice

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Article information

DOI
https://doi.org/10.1039/C2SC20537H
Article type
Edge Article
Submitted
29 Apr 2012
Accepted
29 Jun 2012
First published
29 Jun 2012

Chem. Sci., 2012,3, 2920-2923

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A fluorescent probe for rapid detection of hydrogen sulfide in blood plasma and brain tissues in mice

Y. Qian, L. Zhang, S. Ding, X. Deng, C. He, X. E. Zheng, H. Zhu and J. Zhao, Chem. Sci., 2012, 3, 2920 DOI: 10.1039/C2SC20537H

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