Issue 12, 2012
From the journal:

Chemical Science

Copper-catalyzed olefinic trifluoromethylation of enamides at room temperature†

Chao Fenga  and  Teck-Peng Loh*ab  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637616

b Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China
E-mail: teckpeng@ntu.edu.sg
Fax: +65 6515 8229
Tel: +65 6513 8475

Abstract

Copper-catalyzed olefinic trifluoromethylation and oxytrifluoromethylation of enamides is reported. The direct olefinic C–H trifluoromethylation constitutes an efficient method for the stereoselective synthesis of β-trifluoromethyl substituted enamides.

Graphical abstract: Copper-catalyzed olefinic trifluoromethylation of enamides at room temperature

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Article information

DOI
https://doi.org/10.1039/C2SC21164E
Article type
Edge Article
Submitted
21 Jun 2012
Accepted
01 Sep 2012
First published
03 Sep 2012

Chem. Sci., 2012,3, 3458-3462

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Copper-catalyzed olefinic trifluoromethylation of enamides at room temperature

C. Feng and T. Loh, Chem. Sci., 2012, 3, 3458 DOI: 10.1039/C2SC21164E

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