Issue 12, 2012
From the journal:

Chemical Science

Coordination-responsive selenium-containing polymer micelles for controlled drug release†

Wei Cao,a   Yang Li,b   Yu Yi,a   Shaobo Ji,a   Lingwu Zeng,a   Zhiwei Sun*c  and  Huaping Xu*a  

* Corresponding authors

a Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: xuhuaping@mail.tsinghua.edu.cn
Fax: +86-10 6279 2406
Tel: +86-10 6277 3672

b Department of Toxicology, School of Public Health, Jilin University, Changchun, Jilin 130021, China

c School of Public Health and Family Medicine, Capital Medical University, Beijing 100069, China
E-mail: zwsun@ccmu.edu.cn

Abstract

A novel coordination-responsive system for the controlled release of doxorubicin was fabricated by complexing platinum cations with selenium-containing polymers. Doxorubicin loaded in the platinum-coordinating micelles can be released in a controlled manner through the competitive coordination of the platinum cations with glutathione. The coordination micelles are quite biocompatible as vehicles of drug delivery, thus opening a new avenue in multidrug systems for cooperative chemotherapy.

Graphical abstract: Coordination-responsive selenium-containing polymer micelles for controlled drug release

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Article information

DOI
https://doi.org/10.1039/C2SC21315J
Article type
Edge Article
Submitted
07 Jul 2012
Accepted
27 Aug 2012
First published
30 Aug 2012

Chem. Sci., 2012,3, 3403-3408

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Coordination-responsive selenium-containing polymer micelles for controlled drug release

W. Cao, Y. Li, Y. Yi, S. Ji, L. Zeng, Z. Sun and H. Xu, Chem. Sci., 2012, 3, 3403 DOI: 10.1039/C2SC21315J

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