Issue 8, 2013
From the journal:

Soft Matter

Nanofibrillar thermoreversible micellar microgels†

Diego Velasco,a   Mokit Chau,a   Héloïse Thérien-Aubin,a   Alexander Kumachev,a   Ethan Tumarkin,a   Zhongfan Jia,d   Gilbert C. Walker,a   Michael J. Monteirod  and  Eugenia Kumacheva*abc  

* Corresponding authors

a Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario M5S 3H6, Canada
E-mail: ekumache@chem.utoronto.ca

b Institute of Biomaterials & Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada

c Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario M5S 3E5, Canada

d Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane QLD 4072, Australia
E-mail: m.monteiro@uq.edu.au

Abstract

By using microfluidics, we generated micellar nanofibrillar microgels from solutions of worm-like micelles of poly(N-isopropyl acrylamide)-block-polystyrene. The microgels were formed under physiological conditions (pH = 7.4, 37 °C) and rapidly dissociated upon cooling to 25–27 °C, thereby enabling cell encapsulation and release for further characterization. Our work offers a new concept for the generation of dynamic artificial three-dimensional microenvironments for studies of cell fate.

Graphical abstract: Nanofibrillar thermoreversible micellar microgels

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Article information

DOI
https://doi.org/10.1039/C2SM27796D
Article type
Communication
Submitted
03 Sep 2012
Accepted
10 Dec 2012
First published
03 Jan 2013

Soft Matter, 2013,9, 2380-2383

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Nanofibrillar thermoreversible micellar microgels

D. Velasco, M. Chau, H. Thérien-Aubin, A. Kumachev, E. Tumarkin, Z. Jia, G. C. Walker, M. J. Monteiro and E. Kumacheva, Soft Matter, 2013, 9, 2380 DOI: 10.1039/C2SM27796D

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